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. 2023 Jul 5;9(27):eadf6621. doi: 10.1126/sciadv.adf6621

Fig. 7. Combined tumor cell-intrinsic and cell-extrinsic NR2F6 loss synergize to inhibit melanoma growth.

Fig. 7.

(A and B) B16F10 control (NR2F6 WT) or NR2F6 KO (sg492 and sg495) cells were used to inoculate C57BL/6 control (NR2F6 WT) or NR2F6 KO mice. Tumor volumes (A) and overall animal survival (B) were monitored at indicated time points. n = 8 mice for each group. (C) Violin plots compare the expression of NR2F6, NACC1, and FKBP10 in malignant melanoma cells from patients classified as ICT responders (n = 12) and nonresponders (n = 23). Each dot represents a single malignant cell, and gray horizontal lines are the mean expression in each group. Statistical significance was assessed by two-way ANOVA with Tukey’s test (A), log-rank test (B), or Wilcoxon test (C).