Immunoglobulin titers against SARS-CoV-2 WT-Spike antigen at the pre-vaccine and post- second vaccine timepoints for active treatment, prior treatment, and healthy cohorts including (A) IgM, (B) IgA1, (C) IgG1 and (D) IgG3. (E) Heatmap illustrates relative levels of IgM, IgA1, IgA2, IgG1, IgG3 and IgG4 against Spike, RBD, S1 and S2 proteins for the WT strain of SARS-CoV-2. Antibody levels are shown for Active Treatment, Prior Treatment and Healthy vaccinated groups. MFI data are z-scored across columns, with each row representing a different individual.