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Immunohistochemical analysis of merlin expression in NF2-mutated RCC. Representative histologic sections of tumors (H&E) show solid and papillary architecture with small cells clustering around hyaline material and forming micropapillae surrounded by larger cells and scattered calcifications (a, c). Negative staining of tumor cells for merlin (b, d). The inflammatory cell (b, lower left) renal tubules and Bowman capsule (d, inset) show retained merlin immunoreactivity.
