Table 2.
Characteristics of the overall and subgroup of non-Hispanic White PCOS participants based on menstrual cyclicity.
| All PCOS | NHW PCOS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P value between groupsa | P value between groupsa | |||||||||||
| Variables | Eumeno (n = 12) | Oligo (n = 24) | Ameno (n = 21) | Eumeno vs. Oligo | Oligo vs. Ameno | Eumeno vs. Ameno | Eumeno (n = 12) | Oligo (n = 19) | Ameno (n = 15) | Eumeno vs. Oligo | Oligo vs. Ameno | Eumeno vs. Ameno |
| Age (y) | 24.1 ± 2.3 | 25.7 ± 1.7 | 25.3 ± 1.6 | .841 | .989 | .902 | 24.1 ±2.3 | 26.6 ± 1.9 | 25.1 ± 1.7 | .82 | .893 | .456 |
| BMI (kg/m2) | 33.5 ±2.6 | 35.0 ± 1.7 | 36.3 ± 1.4 | .855 | .855 | .603 | 33.5 ±2.6 | 36.1 ± 1.9 | 37.4 ± 1.8 | .647 | .846 | .932 |
| WHR | 0.83 ± 0.03 | 0.88 ± 0.02 | 0.85 ± 0.02 | .179 | .420 | .789 | 0.83 ± 0.03 | 0.89 ± 0.02 | 0.85 ± 0.03 | .095 | .340 | .786 |
| Ethnicity (n, %) | ||||||||||||
| AA | 0(0) | 5 (20.8) | 6 (28.6) | NA | .799 | NA | NA | NA | NA | NA | NA | NA |
| NHW | 12(100) | 19(79.2) | 15 (74.4) | NA | .799 | NA | NA | NA | NA | NA | NA | NA |
| Hirsutism (mF-G) score | 11.9 ± 1.0 | 11.0 ± 1.0 | 11.1 ± 1.2 | .860 | .998 | .891 | 11.9 ± 1.0 | 11.3 ± 1.3 | 11.3 ± 1.6 | .940 | .999 | .956 |
| Hormonal | ||||||||||||
| Total T (ng/dL) | 76.7 ±4.1 | 80.5 ±3.9 | 98.2 ± 13.6 | .960 | .315 | .310 | 76.7 ±4.1 | 78.5 ±4.6 | 103.3 ± 17.9 | .992 | .217 | .244 |
| Free T (ng/dL) | 0.83 ± 0.08 | 0.93 ± 0.06 | 1.07 ±0.18 | .862 | .688 | .464 | 0.83 ± 0.08 | 0.95 ± 0.07 | 1.14 ±0.24 | .851 | .609 | .366 |
| DHEAS (ng/mL) | 3,626.7 ± 467.3 | 2,525.8 ± 293.2 | 2,496.9 ± 280.7 | .082 | .998 | .081 | 3,626.7 ± 467.3 | 2,662.2 ± 317.3 | 2,678.3 ± 379.5 | .190 | .999 | .232 |
| SHBG (nmol/L) | 16.75 ± 1.49 | 16.31 ±0.96 | 19.15 ±2.75 | .988 | .511 | .713 | 167.5 ± 14.9 | 156.1 ± 10.5 | 180.0 ±35.3 | .936 | .598 | .850 |
| Metabolic | ||||||||||||
| Fasting glucose (mg/L) | 78.6 ± 1.7 | 81.3 ± 1.7 | 89.9 ± 5.0 | .864 | .151 | .107 | 78.6 ± 1.7 | 82.0 ±2.1 | 87.5 ± 3.8 | .665 | .294 | .087 |
| INSo (μlU/mL) | 58.9 ±23.1 | 46.9 ± 10.4 | 47.3 ± 12.5 | .838 | .999 | .863 | 58.9 ±23.1 | 41.9 ±9.9 | 51.1 ± 19.0 | .997 | .986 | .974 |
| kITT (%/min) | 3.33 ±0.51 | 2.63 ± 0.33 | 1.98 ±0.28 | .411 | .341 | .049b | 3.33 ±0.51 | 2.72 ± 0.41 | 1.81 ±0.29 | .597 | .082 | .029 |
| Prevalence of IR (n, %) | 7 (58.3) | 19(79.2) | 19(90.5) | .223 | .337 | .048b | 7 (58.3) | 14(73.7) | 14(93.3) | .204 | .085 | .046 |
Note:Variables are expressed as mean ± standard error of the mean unless otherwise indicated. For thisanalysis P<.05 is considered significant. AA = African American; ameno = amenorrhea; BMI = body mass index; DHEAS = dehydroepiandrosterone sulfate; eumeno = oligo-ovulatory eumenorrhea; INSO = fasting insulin levels; IR = insulin resistance; kITT = rate constant for plasma glucose disappearance during short insulin tolerance test; mF-G = modified Ferriman-Gallwey; NA = not applicable; NHW = Non-Hispanic White; oligo = oligomenorrhea; PCOS = polycystic ovary syndrome; SHBG = sex hormone-binding globulin; T = testosterone; WHR = waist-to-hip ratio.
Unadjusted for age and BMI.
Ezeh. Menstrual cyclicity and dynamic state IR. Fertil Steril 2020.