Fig. 3. Heatmap of MultiSpeciesMotorCortexModel predictions for a subset of 1000 OCRs, clustered by OCR with predictions as features.

Predictions of OCR ortholog open chromatin are shown for 1000 randomly selected motor cortex OCRs with orthologs in at least 75% of species, with each row corresponding to one OCR and each column corresponding to one species. Predictions are shown on a white (closed) to red (open) scale, with missing (species, OCR) pairs shown in light gray. The OCRs (rows) are ordered according to the results of a hierarchical clustering with Ward’s minimum variance method, where the distance between two OCRs was defined as the cosine similarity of activity predictions in species for which both OCRs have usable orthologs (12). Species are ordered by their position in the phylogenetic tree; the approximate positions of species in selected clades are shown along the bottom, and illustrated species are listed in table S26, with the exception of the bat, which is an Egyptian fruit bat. Species colored black are those with data used in model training, and species colored dark gray are those for which we have only predicted open chromatin.