Figure 2. Disease-associated aortic cell types in MFS mice.

Uniform manifold approximation and projection (UMAP) dimensional reduction of (A) SMC and (B) EC clusters extracted from the major cell populations. Dot plots showing top 10 genes highly enriched in SMC (C) and EC subpopulations (D). Dot size corresponds to the percentage of cells expressing each gene, and dot color corresponds to the level of expression. (E) Violin plots showing expression of SMC marker genes (upper) and EC marker genes (lower) in each cell subpopulation of Fbn1^mgR/mgR aortas.