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. 2023 May 22;15(7):998–1005. doi: 10.1038/s41557-023-01205-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Structures of the cγAAs and cβAAs used in this study. b, The reprogrammed codon table that contains ^ClAcy at the initiator AUG codon, and c, γ¹, γ², β¹ and β² at the elongator AUG, GAG, GUG, GUU and UGU codons, respectively. NNA codons are omitted because they were not used in the mRNA library. c, Construction of the random mRNA library and the corresponding peptide library. Peptides spontaneously macrocyclized between ^ClAcy and c via a thioether bond. The mRNA and peptide were covalently linked via a puromycin linker.

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