Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 22;15(7):998–1005. doi: 10.1038/s41557-023-01205-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 3 — a, Each of GM1, GM1γ¹4A, GM2, GM3, GM3γ²10A, GM5, and GM5γ²4A were co-incubated with an internal standard peptide in human serum at 37 °C. At each time point (0, 0.5, 1, 2, 4, 8, 24, 50, and 100 h), the relative intensity of each peptide with respect to the standard peptide was estimated by LC/MS. The relative intensity at 0 h was defined as 100%. Half-lives (t_1/2) were determined by analyzing the mean of 3 technical replicates of each sample by non-linear regression using GraphPad Prism 9. Data are presented as mean values ± SD (n = 3). b,c, Fragments of GM4 (GM4-f1−6) and GM4γ¹4A (GM4γ¹4A-f1−3), respectively, after 24 h incubation in human serum as analyzed by LC/MS.