Table 1.

Binding affinities, inhibitory activities and serum stabilities of the macrocyclic peptides

The thioether-macrocyclic peptides selected by the RaPID system, GM1−GM7, and their mutants are shown. The thioether bond is shown as a blue line where the sulfide atom is omitted. The γ¹ and γ² residues are in red. The table shows sequences, read (%) at the fourth round, kinetic association (k_a), kinetic dissociation (k_d), K_D, IC₅₀ and half-life in human serum (t_1/2). Supplementary Fig. 5 shows the sensorgrams of SPR analysis; Fig. 2a and Extended Data Fig. 2 show the results of the M^pro inhibition assay; Fig. 2b and Extended Data Fig. 3 show the results of serum stability assays. −, the kinetic values could not be accurately determined due to low affinity.