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. 2023 May 31;619(7968):160–166. doi: 10.1038/s41586-023-06123-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, HEK293 cells expressing the indicated KRAS variants were treated as shown and analyzed to determine the effect on KRAS activation. b–d, The indicated cell lines were treated over time to determine the effect on KRAS activation (b–d) and ERK signaling intermediates (d). The cells in b and c were treated in serum-free medium, whereas those in a and d were treated in complete medium. A representative of two independent repeats is shown in a–d.