Extended Data Fig. 2. The effect of GDF15 at 1 and 5 nmol/kg on glucose homeostasis, liver TG, NEFA and ALT.
A, Body weight. Data are means ± SEM, n = 10 mice/group except GDF15 (5 nmol/kg), n = 9 mice. P values by two-way ANOVA with Tukey’s multiple comparisons test. B, Glucose tolerance test (GTT). Data are means ± SEM, n = 10 mice/group except GDF15 (5 nmol/kg), n = 9 mice. P values by one-way ANOVA with Dunnett’s multiple comparisons test. C, Insulin tolerance test (ITT). Data are means ± SEM, n = 10 mice/group except GDF15 (5 nmol/kg), n = 9 mice. P values by one-way ANOVA with Dunnett’s multiple comparisons test. D, Liver triglycerides (TG). Data are means ± SEM, n = 8 mice/group. P values by one-way ANOVA with Dunnett’s multiple comparisons test. E, Liver non-esterified free-fatty acids (NEFA). Data are means ± SEM, n = 10 mice/group except GDF15 (5 nmol/kg), n = 9 mice. P values by one-way ANOVA with Dunnett’s multiple comparisons test. F, Serum alanine aminotransferase (ALT). Data are means ± SEM, n = 10 mice/group except GDF15 (5 nmol/kg), n = 9 mice. P values by one-way ANOVA with Dunnett’s multiple comparisons test.