Fig.2. Associations between serum ALP levels and incident CVD, CHD, and stroke in subgroups in men and women.

Stratified analysis for the association between serum ALP levels and incident CVD, CHD, and stroke among men (a, b, and c) and women (d, e, and f) with comparison of the extreme quartiles. All models were adjusted for age, BMI, smoking status, drinking status, physical activity, hypertension, hyperlipidemia, diabetes, aspirin usage, anticoagulants usage, menopausal status (women only), family history of CVD, eGFR, WBC, and admission batch (except for the corresponding stratified variables). Interactions were tested by including a multiplicative interaction term in the model. Ever-smokers included current and former smokers, and ever-drinkers included current and former drinkers. The total number and the number of events for each stratification characteristic were slightly different because of missing values for BMI, smoking status, drinking status, and eGFR. The quartiles of ALP levels in men were Q1 (＜69 U/L), Q2 (69–84 U/L), Q3 (84–100 U/L), and Q4 (＞100 U/L), whereas the quartiles of ALP levels in women were Q1 (＜71 U/L), Q2 (71–87 U/L), Q3 (87–105 U/L), and Q4 (＞105 U/L), respectively.