Table 2. Factor Ⅺ (a) inhibitors for thrombosis^§ .

	Small molecules	Monoclonal antibodies	Aptamers	Antisense oligonucleotides	Natural inhibitors
Mechanism of action	Direct inhibition of FXIa	Direct inhibition of FXI/FXIa	Direct inhibition of FXIa	Inhibition of FXI biosynthesis	Direct inhibition of FXIa
Route of administration	IV or Oral	IV or SC	IV or SC	SC	IV
Dosing	Daily	Monthly	Daily	Weekly	Daily
Onset of action	Minutes/Hours	Hours	Minutes/Hours	Weeks	Minutes
Offset of action	Minutes/Hours	Weeks	Minutes/Hours	Weeks	Hours
Medication name	Asundexian	Osocimab	FELIAP	ISIS-FXIRx	Fasxiator
	Milvexian	Abelacimab	29 nt 11.16	Fesomersen	Ir-CPI
	ONO-7684	Xisomab	40-nt 12.7
		MK-2060

Abbreviations: IV, intravenous; SC, subcutaneous

^§Table 2 adapted from [61].