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. 2023 May 26;163(2):327–338. doi: 10.1007/s11060-023-04341-3

Fig. 1.

Fig. 1

Identification of 4 (phospho-)protein clusters in GBM samples. (A) Elbow plot indicates the relative change in area under CDF curve vs. the k clusters. (B) Unsupervised CNF clustering for N = 126 samples indicates 4 distinct clusters. Boxplots reveal higher median expression of protein levels at cluster 1 for BCLXL (C), SMAC/DIABLO (D), and PARP (E); cluster 2 for HIF1α (F), AMPKα (G), and CIAP (H); cluster 3 for VEGFREC2 (I); and cluster 4 for mTOR(2481) (J). Likelihood-ratio t-test was used to calculate the significant difference between each cluster (ANOVA, Tukey HSD p-adjust. < 0.05)