| Our simulations indicate that at least 14 days are needed to reach maximal induction and to return to CYP3A4 baseline enzymes levels in the presence of an inducer. This implies that an inducer should be administered for at least 14 days before conducting drug–drug interaction studies to reach maximal induction. |
| Our results also support the common practice of maintaining the adjusted dosage of a drug for another 2 weeks upon discontinuation of an inducer. |
| The time to reach maximal induction and resolution of induction is shorter for UGT1A1. |
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