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. 2023 Jun 7;97(8):2219–2230. doi: 10.1007/s00204-023-03531-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Pgp inhibition by rifampicin (open circles) or rifabutin (filled circles) in P388/dx cells (E_max model fit, solid line) and P388 cells (simply connected by dashed lines) cells. Zosuquidar (10 µM; white diamond, evaluated in P388/dx cells) was used as a positive control. Data shown are the mean ± SEM of independent biological replicates with n = 8. Data were fitted to an E_max model (four parameter-logistic equation with variable slope). Individual IC₅₀ values are listed in Supplemental Material Table S7