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. 2023 Jul 5;14:3684. doi: 10.1038/s41467-023-39132-x

Fig. 8. Visualization of tissue-specific expression levels of select GPCRs with high basal activities, serine/threonine kinases, β-arrestin-1 and β-arrestin−2.

Fig. 8

Human Protein Atlas (HPA) RNA consensus tissue gene data (version 21.0 and Ensembl version 103.38.) summarizing the expression levels in 55 tissues was extracted for β-arrestin-1 and −2 (ARRB1 and ARRB2), select receptors with high constitutive selectivity for one arrestin isoform over the other (GPR182, AGTR2, ADRA2A, GPR37L1, SCTR, ADRB3, PTGER4, SUNCR1, PTGER3, MRGPRG, NPY5R, NPY1R, GLP1R, FPR1, MC1R, FPR3, 5-HT5, MRGPRD, GPR87, CXCR4, HRH1, AVPR2, 5-HT4, 5-HT2A, NTSR1, GLP2R, 5-HT1D, CXCR2, 5-HT1B, 5-HT1E, PTGER2, 5-HT2B, PTGDR), and either and either GRKs (a), PKA (b), PKCs, PKNs, and PKDs (c), PKGs (d), PIMs (e), AKTs (f), GSK3 (g), CAMKI, CAMKII, and CAMIV (h), CK1s and CK2s (i). The data was analyzed using principal component analysis; β-arrestin-1 and −2 are denoted with red, ST kinases with blue, and GPCRs with orange symbols. Generic receptor codes refer to the GPCR-Tango constructs.