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. 2023 Jul 5;14:3956. doi: 10.1038/s41467-023-39652-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Heatmaps show significant (FDR <0.05) GO terms associated with disease duration in PD caudate (a) and putamen (b), identified by spline regression analysis. Scaled expression (log₂(cpm)) values are plotted. y years. c, d Scatter plots show GSVA enrichment scores for top significant GO terms plotted against disease duration in caudate (c) and putamen (d). Blue lines indicate loess regression lines, with 95% confidence intervals shaded in gray. Source data are provided as a Source Data file.