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. 2023 Jul 5;14(7):399. doi: 10.1038/s41419-023-05906-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Mouse islets were exposed to BMP-2 (50 pg/ml) or left non-exposed for 10 days. A Volcano plot representing the differential expressed RNA’s between BMP-2 vs. ctr exposed mouse islets. X-axis: log2 gene expression fold-change, Y-axis: −log10 p value. Each dot represents an individual RNA. Gray: not significantly regulated genes, green: FDR <0.05 upregulated genes, and red FDR <0.05 downregulated genes. Selected regulated genes by BMP-2 are marked. B Table showing the summary of genes regulated by BMP-2. C, D Top ten most significantly enriched biological processes GO of BMP-2 upregulated and downregulated genes, respectively. X-axis: Percent of genes in the GO significantly regulated by BMP-2. Circle size: Number of significant BMP-2 regulated genes in the GO.