Table 1.
Top 35 most regulated proteins and corresponding genes expression by BMP-2.
| Gene name | Protein name | Abundance protein Ratio: (BMP2) / (Control) | Abundance protein Ratio Adj. P-Value: (BMP2) / (Control) | Abundance mRNA Ratio: (BMP2) / (Control) | Abundance mRNA Ratio Adj. P-Value: (BMP2) / (Control) | |
|---|---|---|---|---|---|---|
| Top 35 most upregulated proteins and corresponding genes by BMP2: | ||||||
| 1 | Abcg2 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | 7,83 | 0,000001 | 19,46 | 0,000618 |
| 2 | H1-4 | Histone H1.4 | 5,81 | 0,005678 | N.A | N.A |
| 3 | Ca15 | Carbonic anhydrase 15 | 5,10 | 0,000066 | 6,49 | 0,000618 |
| 4 | Mxra7 | Matrix-remodeling-associated protein 7 | 3,97 | 0,000062 | 9,64 | 0,000618 |
| 5 | S100a6 | Protein S100-A6 | 3,71 | 0,019002 | 3,26 | 0,013735 |
| 6 | Rpl14 | 60 S ribosomal protein L14 | 3,40 | 0,074282 | 0,97 | 0,894231 |
| 7 | Apoa5 | Apolipoprotein A-V | 3,29 | 0,000142 | 99,64 | 0,000618 |
| 8 | Krt20 | Keratin, type I cytoskeletal 20 | 3,11 | 0,020971 | 24,75 | 0,377516 |
| 9 | Vstm2l | V-set and transmembrane domain-containing protein 2-like protein | 3,08 | 0,007263 | 1,63 | 0,000618 |
| 10 | Dap | Death-associated protein 1 | 3,00 | 0,004513 | 1,12 | 0,401089 |
| 11 | Calb1 | Calbindin | 2,93 | 0,000001 | 4,01 | 0,000618 |
| 12 | Lsm6 | U6 snRNA-associated Sm-like protein LSm6 | 2,86 | 0,029078 | 0,94 | 0,748914 |
| 13 | Iqgap2 | Ras GTPase-activating-like protein IQGAP2 | 2,81 | 0,000003 | 6,42 | 0,000618 |
| 14 | Spock2 | Testican-2 | 2,66 | 0,000031 | 2,27 | 0,000618 |
| 15 | Rps20 | 40 S ribosomal protein S20 | 2,61 | 0,032729 | 0,87 | 0,331214 |
| 16 | H2ac20 | Histone H2A type 2-C | 2,60 | 0,016075 | N.A | N.A |
| 17 | Rpl34 | 60 S ribosomal protein L34 | 2,59 | 0,052033 | 0,95 | 0,957406 |
| 18 | Tppp3 | Tubulin polymerization-promoting protein family member 3 | 2,42 | 0,048060 | 3,72 | 0,000618 |
| 19 | Gsta1 | Glutathione S-transferase A1 | 2,41 | 0,081305 | N.A | N.A |
| 20 | Anxa10 | Annexin A10 | 2,37 | 0,026457 | 3,55 | 0,119353 |
| 21 | Ptgr1 | Prostaglandin reductase 1 | 2,37 | 0,009449 | 3,64 | 0,000618 |
| 22 | Isoc1 | Isochorismatase domain-containing protein 1 | 2,25 | 0,056079 | N.A | N.A |
| 23 | Igfbp5 | Insulin-like growth factor-binding protein 5 | 2,20 | 0,005785 | 5,13 | 0,000618 |
| 24 | Gpr180 | Integral membrane protein GPR180 | 2,14 | 0,028357 | 0,80 | 0,043977 |
| 25 | Osbpl10 | Oxysterol-binding protein-related protein 10 | 2,08 | 0,000083 | N.A | N.A |
| 26 | Acyp1 | Acylphosphatase-1 | 2,02 | 0,029866 | 1,20 | 0,272694 |
| 27 | Sult1d1 | Sulfotransferase 1 family member D1 | 2,02 | 0,001639 | 2,38 | 0,000618 |
| 28 | Syt7 | Synaptotagmin-7 | 2,01 | 0,000264 | 1,84 | 0,000618 |
| 29 | Dpy30 | Protein dpy-30 homolog | 1,97 | 0,064369 | 1,01 | 0,966752 |
| 30 | Uevld | Ubiquitin-conjugating enzyme E2 variant 3 | 1,96 | 0,060962 | 0,92 | 0,784857 |
| 31 | Zdhhc2 | Palmitoyltransferase ZDHHC2 | 1,96 | 0,001802 | 1,23 | 0,048838 |
| 32 | Krt19 | Keratin, type I cytoskeletal 19 | 1,91 | 0,073123 | 0,44 | 0,012744 |
| 33 | Ces2c | Acylcarnitine hydrolase | 1,90 | 0,050217 | N.A | N.A |
| 34 | S100a1 | Protein S100-A1 | 1,89 | 0,002433 | 2,03 | 0,000618 |
| 35 | Sumo1 | Small ubiquitin-related modifier 1 | 1,89 | 0,025861 | 1,13 | 0,424157 |
| Top 35 most downregulated proteins and corresponding genes by BMP2: | ||||||
| 1 | Stmn1 | Stathmin | 0,24 | 0,000052 | 0,03 | 0,198626 |
| 2 | C1qa | Complement C1q subcomponent subunit A | 0,30 | 0,000045 | 0,02 | 0,000618 |
| 3 | Ppp4r4 | Serine/threonine-protein phosphatase 4 reg. subunit 4 | 0,39 | 0,007247 | 0,51 | 0,000618 |
| 4 | Vgf | Neurosecretory protein VGF | 0,45 | 0,000007 | 0,06 | 0,000618 |
| 5 | Psat1 | Phosphoserine aminotransferase | 0,45 | 0,000213 | 0,37 | 0,000618 |
| 6 | Nptx2 | Neuronal pentraxin-2 | 0,47 | 0,000305 | 0,02 | 0,000618 |
| 7 | Eef1b | Elongation factor 1-beta | 0,47 | 0,076116 | 0,93 | 0,647443 |
| 8 | Mcm2 | DNA replication licensing factor MCM2 | 0,47 | 0,000095 | 0,42 | 0,000618 |
| 9 | Mcm6 | DNA replication licensing factor MCM6 | 0,47 | 0,000153 | 0,42 | 0,000618 |
| 10 | Eri1 | 3'-5' exoribonuclease 1 | 0,49 | 0,037395 | 0,82 | 0,174334 |
| 11 | Nefm | Neurofilament medium polypeptide | 0,49 | 0,000197 | 0,25 | 0,000618 |
| 12 | Gcg | Pro-glucagon | 0,51 | 0,000596 | 0,32 | 0,000620 |
| 13 | Prom1 | Prominin-1 | 0,51 | 0,000317 | 0,19 | 0,000618 |
| 14 | Mcn3 | DNA replication licensing factor MCM3 | 0,53 | 0,000420 | 0,13 | 0,000618 |
| 15 | Rif1 | Telomere-associated protein RIF1 | 0,55 | 0,010896 | 1,00 | 0,980331 |
| 16 | Dgkg | Diacylglycerol kinase gamma | 0,55 | 0,000732 | 0,47 | 0,000618 |
| 17 | Dmd | Dystrophin | 0,56 | 0,024898 | 0,61 | 0,007054 |
| 18 | Dbn1 | Drebrin | 0,56 | 0,000064 | 0,44 | 0,000618 |
| 19 | Creld2 | Protein disulfide isomerase Creld2 | 0,56 | 0,001105 | 0,45 | 0,000618 |
| 20 | Gpx3 | Glutathione peroxidase 3 | 0,57 | 0,007145 | 0,30 | 0,000618 |
| 21 | Eppk1 | Epiplakin | 0,57 | 0,000756 | 0,45 | 0,034942 |
| 22 | Cgref1 | Cell growth regulator with EF hand domain protein 1 | 0,58 | 0,000560 | 0,55 | 0,836251 |
| 23 | Rps25 | 40 S ribosomal protein S25 | 0,59 | 0,002133 | 1,53 | 0,269735 |
| 24 | Dync1i1 | Cytoplasmic dynein 1 intermediate chain 1 | 0,60 | 0,000162 | 0,44 | 0,000618 |
| 25 | Ap1s1 | AP-1 complex subunit sigma-1A | 0,60 | 0,000025 | 0,44 | 0,000618 |
| 26 | Nudt7 | Peroxisomal coenzyme A diphosphatase NUDT7 | 0,60 | 0,000271 | 0,87 | 0,411039 |
| 27 | Tmem165 | Transmembrane protein 165 | 0,60 | 0,004953 | 0,72 | 0,001174 |
| 28 | Ephx1 | Epoxide hydrolase 1 | 0,61 | 0,000104 | 0,76 | 0,017847 |
| 29 | Rassf2 | Ras association domain-containing protein 2 | 0,61 | 0,001264 | 0,26 | 0,000618 |
| 30 | Erich5 | Glutamate-rich protein 5 | 0,61 | 0,000294 | 0,53 | 0,062129 |
| 31 | Spock1 | Testican-1 | 0,61 | 0,016193 | 0,46 | 0,000618 |
| 32 | Enpp2 | Ectonucleotide phosphodiesterase family member 2 | 0,62 | 0,000153 | 0,34 | 0,000618 |
| 33 | Sst | Somatostatin | 0,63 | 0,075366 | 0,37 | 0,000618 |
| 34 | Oat | Ornithine aminotransferase, mitochondrial | 0,63 | 0,000717 | 0,52 | 0,000618 |
| 35 | Rcn1 | Reticulocalbin-1 | 0,64 | 0,000089 | 0,52 | 0,000618 |
Table showing the top 35 most regulated proteins with corresponding mRNA expression and related adjusted p-value. N.A= no corresponding mRNA detected.