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. 2023 Jul 5;13:10883. doi: 10.1038/s41598-023-37925-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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This figure depicts voxels that were selected by comparing AIC statics of the 4 ageing models under study. Only voxels with sufficient model fit (Chi-square p > 0.05) exhibiting non-corrupt correlations between latent factors (r < 1 and r > − 1) were depicted within the confines of the skeletonized white matter (FA > 0.2). Voxels related to the cognitive mediation model are depicted in red while voxels of independent factor model are depicted in blue. (A) Depicts the caudal dorsal bird's-eye view of voxels related to the cognitive mediation model thresholded at a volume of 300 mm³. (B) Depicts the caudal dorsal bird's-eye view of voxels related to the cognitive mediation model and independent factor model thresholded at a volume of 300 mm³. (C) Depicts voxels related to the cognitive mediation model that were found within the confines of the postcentral /cerebellum white matter tract as described by the IIT Human Brain Atlas thresholded at a volume of 120 mm³. (D) Depicts the rostral dorsal bird's-eye view of both models within the confines of the cingular fibers as described by the IIT Human Brain Atlas thresholded at a volume 300 mm³.