FIGURE 9.
Intraperitoneal (IP) transfer of microRNA (miR)‐29b‐containing small extracellular vesicles (sEV) suppresses peritoneal metastasis in a mouse syngeneic model. C57BL6/N mice were IP injected with YTN16P (1.0 × 105 cells, 500 μL) and then IP injected with PBS (500 μL) or sEV (40 μg/500 μL) isolated from murine bone marrow‐derived mesenchymal stem cells transfected with lentivirus integrating miRNA‐29b (Exo‐miR‐29b) or negative control (Exo miR‐NC) every 3 days from day 0 to day 18. Mice were killed on day 21 and peritoneal metastases were evaluated based on the number of macroscopic nodules on the mesentery and the omental surface. Data show mean ± SD in one of the two different experiments. *p < 0.05. No trtmt, without treatment.