TABLE 2.
Categories of biomarkers for predicting ATRi efficacy.
| Biomarkers associated with cell signaling pathways activated in response to replication stress | p‐ATR |
| p‐Chk1 | |
| p‐RPA32 | |
| γH2A.X | |
| Biomarkers of genetic alterations leading to replication stress | MYC overexpression |
| RAS mutation | |
| Cyclin E overexpression | |
| APOBEC3A/B overexpression | |
| EWS translocation | |
| MLL translocation | |
| Biomarkers of loss of function in DNA repair and DDR | ARID1A deficiency |
| RNASEH2 deficiency | |
| ATM deficiency | |
| p53 deficiency | |
| ERCC1 deficiency | |
| XRCC1 deficiency | |
| PARPi‐ or platinum‐resistant BRCA1/2 deficiency | |
| RAD51 deficiency | |
| SLFN11 deficiency | |
| SMARCA4 deficiency | |
| Biomarkers resistant to ATRis | CDC25A deficiency |
| UPF2 deficiency |