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Hub gene selection and prognostic model construction. (A) Volcano map showing differentially expressed genes in cluster 2, with red dots representing differentially upregulated genes. (B) Protein–protein interaction (PPI) network of cluster 2's differentially upregulated genes. (C) Top 100 core genes in PPI obtained by Degree and MNC topological algorithms. (D, E) LASSO regression analysis selected the optimal prognostic biomarkers from 100 hub genes.
