TABLE 2.
Inhibitors targeting autophagy‐related factors.
Targeted ATG | Compound | IC50 | Reference |
---|---|---|---|
ULK1/ULK2 | SBI‐0206965 | 108 nM/711 nM | 69 |
MRT67307 | 45 nM/38 nM | 70 | |
MRT68921 | 2.9 nM/1.1 nM | ||
Compound 6 | 8 nM/− | 71 | |
ULK‐100 | 1.6 nM/2.6 nM | 72 | |
ULK‐101 | 8.3 nM/30 nM | ||
VPS34 | SAR405 | 1.2 nM | 73 |
VPS34‐IN1 | 25 nM | 74 | |
PIK‐III | 18 nM | 75 | |
Compound 31 | 2 nM | 76 | |
SB02024 | 14 nM | 77 | |
ATG7 | Compound 18 | 48 nM | 78 |
Compound 19 | 52 nM | ||
Compound 37 | 62 nM | ||
Atg4A/Atg4B | NSC185058 | −/50 μM | 79 |
Tioconazol | 1.3 μM/1.8 μM | 80 | |
LV320 | 35.5 μM/24.5 μM | 81 | |
S130 | 7.11 μM/3.24 μM | 82 | |
FMK‐9a | −/80 nM | 83 | |
UAMC‐2526 | −/− | 84 | |
ATG4B‐LC3 PPI | SUPR4B1W | 120 nM (KD) | 85 |
ATG5‐ATG16L1 PPI | Peptide 10 | 12 nM (KD) | 86 |
Beclin1‐ATG14L PPI | Cmpound 19 | 33.9 uM | 87 |
Note: (−): not applicable, not available.