Table 3.
Diagnostic performance of TTV load using the previously determined cut-off (≥3.45 log10 copies/ml) for prediction of CMV reactivation in R+ KTR.
| Cut-off (log10 copies/ml) | Time point | Follow-up | Sensitivity* %[95% CI] | Specificity* % [95% CI] | PPV* % [95% CI] | NPV* % [95% CI] |
|---|---|---|---|---|---|---|
| TTV ≥ 3.45 | D0 | D0–M6 | 57.1 [28.9; 82.3] | 60.0 [44.3; 74.3] | 30.8 [14.3; 51.8] | 81.8 [64.5; 93.0] |
| D0 | D0–M12 | 63.2 [38.4; 83.7] | 65.0 [48.3; 79.4] | 46.2 [26.6; 66.6] | 78.8 [61.1; 91.0] | |
| M1 | M1–M4 | 75.0 [34.9; 96.8] | 46.0 [31.8; 60.7] | 18.2 [7.0; 35.5] | 92.0 [74.0; 99.0] | |
| M1 | M1–M6 | 72.7 [39.0; 94.0] | 46.8 [32.1; 61.9] | 24.2 [11.1; 42.3] | 88.0 [68.8; 97.4] | |
| M1 | M1–M12 | 78.6 [49.2; 95.3] | 50.0 [34.6; 65.4] | 33.3 [18.0; 51.8] | 88.0 [68.8; 97.5] |
PPV, positive predictive value; NPV, negative predictive value; and CI, confidence interval.
*
Calculated in patients with data available over the study period.