Table 4.
Diagnostic performance of TTV load using optimized cut-offs determined by ROC curves for prediction of CMV reactivation in R+ KTR.
| Cut-off (log10 copies/ml) | AUC | Time point | Follow-up | Sensitivity* % [95% CI] | Specificity* % [95% CI] | PPV* % [95% CI] | NPV* % [95% CI] |
|---|---|---|---|---|---|---|---|
| TTV ≥ 3.97 | 0.56 | D0 | D0–M6 | 57.1 [28.9; 82.3] | 71.1 [55.7; 83.6] | 38.1 [18.1; 61.6] | 84.2 [68.7; 94.0] |
| TTV > 3.78 | 0.65 | D0 | D0–M12 | 63.2 [38.4; 83.7] | 72.5 [56.1; 85.4] | 52.2 [30.6; 73.2] | 80.6 [64.0; 91.8] |
| TTV ≥ 4.27 | 0.63 | M1 | M1–M4 | 75.0 [34.9; 96.8] | 56.0 [41.2; 70.0] | 21.4 [8.3; 40.9] | 93.3 [77.9; 99.2] |
| TTV ≥ 4.27 | 0.63 | M1 | M1–M6 | 72.7 [39.0; 94.0] | 57.4 [42.2; 71.7] | 28.6 [13.2; 48.7] | 90.0 [73.5; 97.9] |
| TTV > 4.23 | 0.70 | M1 | M1–M12 | 78.6 [49.2; 95.3] | 61.4 [45.5; 75.6] | 39.2 [21.5; 59.4] | 90.0 [73.5; 97.9] |
| TTV > 0.75 | 0.60 | D0 to M1 | M1–M12 | 78.6 [49.2; 95.3] | 48.7 [32.4; 65.2] | 35.5 [35.5; 19.2] | 86.4 [65.1; 97.1] |
AUC, Area under the ROC Curve; PPV, positive predictive value; NPV, negative predictive value; and CI, confidence interval.
*
Calculated in patients with data available over the study period.