Table 6.

Diagnostic performance of the QF-Ag or the QF-Mg at M1 using optimized cut-offs determined by ROC curves for prediction of CMV reactivation in the R+ KTR cohort.

Cut-off (IU/ml)	AUC	Time point	Follow-up	Sensitivity* % [95% CI]	Specificity* % [95% CI]	PPV* % [95% CI]	NPV* % [95% CI]
QF-Ag < 2.23	0.53	M1	M1–M4	62.5 [24.5; 91.5]	52.0 [37.4; 66.3]	17.2 [5.8; 35.8]	89.7 [72.7; 97.8]
QF-Ag < 9.12	0.56	M1	M1–M6	90.9 [58.7; 99.8]	27.7 [15.6; 42.6]	22.7 [11.5; 37.8]	92.9 [66.1; 99.8]
QF-Ag ≤ 2.48	0.61	M1	M1–M12	71.4 [41.9; 91.6]	54.5 [38.8; 69.6]	33.3 [17.3; 52.8]	85.7 [67.3; 95.6]
QF-Mg < 1.29	0.61	M1	M1–M4	62.5 [24.5; 91.5]	68.0 [53.3; 80.5]	23.8 [8.2; 47.2]	91.9 [78.1; 98.3]
QF-Mg < 1.29	0.69	M1	M1–M6	72.7 [39.0; 94.0]	72.3 [57.4; 84.4]	38.1 [18.1; 61.6]	91.9 [78.1; 98.3]
QF-Mg ≤ 1.27	0.68	M1	M1–M12	64.3 [35.1; 87.2]	72.7 [57.2; 85.0]	42.9 [21.8; 66.0]	86.5 [71.2; 95.5]

AUC, Area under the ROC Curve; PPV, positive predictive value; NPV, negative predictive value; and CI, confidence interval.

^*Calculated in patients with data available over the study period.