Table 7.
Diagnostic performance of the QF-Ag or QF-Mg and TTV load analyzed in combination at M1 for prediction of CMV reactivation in R+ KTR.
| Cut-off (QF-CMV: IU/ml, TTV: log10 copies/ml) | Time point | Follow-up | Sensitivity* % [95% CI] | Specificity* % [95% CI] | PPV* % [95% CI] | NPV* % [95% CI] |
|---|---|---|---|---|---|---|
| QF-Ag < 0.2 and TTV ≥ 3.45 | M1 | M1–M4 | 25.0 [3.2; 65.0] | 85.7 [72.8; 94.1] | 22.2 [2.8; 60.0] | 87.5 [74.7; 95.3] |
| M1 | M1–M6 | 27.3 [6.0; 61.0] | 87.0 [73.7; 95.1] | 33.3 [7.5; 70.1] | 83.3 [70.0; 92.5] | |
| M1 | M1–M12 | 28.6 [8.4; 58.1] | 88.4 [74.9; 96.1] | 44.4 [13.7; 78.8] | 79.2 [65.0; 89.5] | |
| QF-Mg < 0.5 and TTV ≥ 3.45 | M1 | M1–M4 | 37.5 [8.5; 75.5] | 89.8 [77.8; 96.6] | 37.5 [8.5; 75.5] | 89.8 [77.8; 96.6] |
| M1 | M1–M6 | 36.4 [10.9; 69.2] | 91.3 [79.2; 97.6] | 50.0 [15.7; 84.3] | 91.3 [72.8; 94.1] | |
| M1 | M1–M12 | 35.7 [12.8; 64.9] | 93.0 [80.9; 98.5] | 62.5 [24.5; 91.5] | 81.6 [68.0; 91.2] |
The diagnostic accuracy of the combination of markers was assessed using QF-CMV manufacturer’s cut-offs and the previously determined TTV cut-offs. PPV, positive predictive value; NPV, negative predictive value; and CI, confidence interval.
*
Calculated in patients with data available over the study period.