Table 8.
Diagnostic performance of the QF-Ag or QF-Mg and TTV load analyzed in combination at M1 for prediction of CMV reactivation in R+ KTR.
| Cut-off (QF-CMV: IU/ml,TTV: log10 copies/ml) | Time point | Follow-up | Sensitivity* % [95% CI] | Specificity* % [95% CI] | PPV* % [95% CI] | NPV* % [95% CI] |
|---|---|---|---|---|---|---|
| QF-Ag < 2.23 and TTV ≥ 4.27 | M1 | M1–M4 | 50.0 [15.7; 84.3] | 79.6 [65.7; 89.8] | 28.6 [8.4; 58.1] | 90.7 [77.9; 97.4] |
| QF-Ag < 9.12 and TTV ≥ 4.27 | M1 | M1–M6 | 63.6 [30.8; 89.1] | 69.6 [54.2; 82.3] | 33.3 [14.6; 57.0] | 88.9 [73.9; 97.0] |
| QF-Ag ≤ 2.48 and TTV > 4.23 | M1 | M1–M12 | 64.3 [35.1; 87.2] | 86.0 [72.1; 94.7] | 60.0 [32.3; 83.7] | 88.1 [74.4; 96.0] |
| QF-Mg < 1.29 and TTV ≥ 4.27 | M1 | M1–M4 | 37.5 [8.5; 75.5] | 87.8 [75.2; 95.4] | 33.3 [7.5; 70.1] | 89.6 [77.3; 96.5] |
| QF-Mg < 1.29 and TTV ≥ 4.27 | M1 | M1–M6 | 45.4 [16.8; 76.6] | 91.3 [79.2; 98.6] | 55.6 [21.2; 86.3] | 87.5 [74.7; 95.3] |
| QF-Mg ≤ 1.27 and TTV > 4.23 | M1 | M1–M12 | 42.9 [17.7; 71.1] | 93.0 [80.9; 98.5] | 66.7 [29.9; 92.5] | 83.3 [70.0; 92.5] |
The diagnostic accuracy of the combination of markers was assessed using the optimal QF-CMV and TTV cut-offs determined by ROC curves. Abbreviations: AUC, Area under the ROC Curve; PPV, positive predictive value; NPV, negative predictive value; and CI, confidence interval.
*
Calculated in patients with data available over the study period.