Table 2. Univariable and multivariable cox regression: 20-year survival.
| Variable | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| Hazard ratio | P value | Hazard ratio | P value | ||
| Recipient factors | |||||
| Age (years) | |||||
| 18–24 | 0.94 | 0.352 | |||
| 25–34 | 0.64 | <0.001 | 0.77 | <0.001 | |
| 35–44 | 0.74 | <0.001 | 0.83 | <0.001 | |
| 45–54 | 0.96 | 0.117 | |||
| 55–64 | 1.47 | <0.001 | 1.24 | <0.001 | |
| ≥65 | 1.65 | <0.001 | 1.51 | <0.001 | |
| Blood group | |||||
| A | 0.94 | 0.016 | 1.04 | 0.497 | |
| B | 0.94 | 0.117 | |||
| O | 1.07 | 0.011 | 1.11 | 0.048 | |
| AB | 1.15 | 0.030 | 1.23 | 0.015 | |
| BMI | |||||
| <18.5 | 0.86 | <0.001 | 0.92 | 0.524 | |
| 18.5–24.9 | 0.93 | 0.008 | 0.87 | 0.287 | |
| 25.0–29.9 | 1.17 | <0.001 | 1.00 | 0.971 | |
| 30.0–34.9 | 1.13 | 0.014 | 0.97 | 0.828 | |
| 35.0–39.9 | 1.02 | 0.847 | |||
| ≥40.0 | 1.56 | 0.183 | |||
| Diagnosis | |||||
| Alpha-1-antitrypsin deficiency | 0.94 | 0.181 | |||
| COPD/emphysema | 1.39 | <0.001 | 1.10 | 0.036 | |
| Cystic fibrosis | 0.65 | <0.001 | 1.08 | 0.222 | |
| IPF/UIP | 1.16 | <0.001 | 1.02 | 0.733 | |
| Pulmonary hypertension | 0.77 | <0.001 | 0.99 | 0.941 | |
| GFR (mL/min) | |||||
| <10 | 1.86 | 0.004 | 1.87 | 0.021 | |
| 10–19 | 1.00 | 0.989 | |||
| 20–29 | 1.29 | 0.238 | |||
| 30–39 | 0.97 | 0.801 | |||
| 40–49 | 0.94 | 0.462 | |||
| ≥50 | 0.99 | 0.813 | |||
| Life support before transplant | 0.82 | 0.012 | 0.91 | 0.278 | |
| Waitlist time | |||||
| <6 months | 1.15 | <0.001 | 0.96 | 0.389 | |
| 6 months to 1 year | 1.13 | <0.001 | Reference | ||
| 1–2 years | 0.91 | 0.002 | 0.90 | 0.016 | |
| >2 years | 0.75 | <0.001 | 0.79 | <0.001 | |
| Donor/transplant factors | |||||
| Donor age (years) | |||||
| <15 | 0.91 | 0.134 | |||
| 15–24 | 0.96 | 0.092 | |||
| 25–34 | 0.95 | 0.169 | |||
| 35–44 | 1.07 | 0.047 | 1.04 | 0.366 | |
| 45–54 | 1.07 | 0.072 | |||
| ≥55 | 1.14 | 0.052 | |||
| Donor cause of death | |||||
| CVA | 1.07 | 0.019 | Reference | ||
| Anoxia | 0.84 | 0.010 | 0.87 | 0.058 | |
| Head trauma | 0.94 | 0.020 | 0.92 | 0.009 | |
| Donor cigarette use | 1.09 | 0.011 | 1.08 | 0.025 | |
| Donor ethnicity: African American | 1.07 | 0.001 | 1.04 | 0.082 | |
| Donor GFR (mL/min) | |||||
| <10 | 0.92 | 0.489 | |||
| 10–19 | 1.12 | 0.367 | |||
| 20–29 | 1.26 | 0.012 | 1.27 | 0.023 | |
| 30–39 | 1.01 | 0.931 | |||
| 40–49 | 1.01 | 0.924 | |||
| ≥50 | 0.96 | 0.261 | |||
| Gender match | |||||
| Male to male | 1.06 | 0.035 | 0.95 | 0.144 | |
| Male to female | 1.08 | 0.080 | |||
| Female to male | 0.97 | 0.458 | |||
| Female to female | 0.88 | <0.001 | 0.89 | 0.003 | |
| ABO incompatible | 1.02 | 0.968 | |||
| HLA mismatch level | |||||
| 0 | 0.70 | 0.614 | |||
| 1 | 0.85 | 0.364 | |||
| 2 | 0.91 | 0.182 | |||
| 3 | 0.92 | 0.029 | 0.89 | 0.010 | |
| 4 | 1.00 | 0.931 | |||
| 5 | 1.02 | 0.522 | |||
| 6 | 1.06 | 0.067 | |||
| Ischemic time (hours) | |||||
| <1.0 | 1.06 | 0.735 | |||
| 1.0–1.9 | 1.34 | <0.001 | 1.20 | 0.013 | |
| 2.0–2.9 | 1.20 | <0.001 | 1.05 | 0.342 | |
| 3.0–3.9 | 1.19 | <0.001 | 1.05 | 0.232 | |
| 4.0–4.9 | 0.99 | 0.758 | |||
| ≥5.0 | 0.75 | <0.001 | 1.00 | 0.924 | |
| Size match: undersized donor | 1.00 | 0.956 | |||
| Size match: oversized donor | 1.03 | 0.429 | |||
| Unilateral lung transplant | 1.68 | <0.001 | 1.30 | <0.001 | |
P<0.05 is significant on multivariable analysis. BMI, body mass index; COPD, chronic obstructive pulmonary disease; IPF/UIP, idiopathic pulmonary fibrosis/usual interstitial pneumonitis; GFR, glomerular filtration rate; CVA, cerebrovascular accident; HLA, human leukocyte antigen.