Table 3. Univariable and multivariable cox regression: 10-year survival.
| Variable | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| Hazard ratio | P value | Hazard ratio | P value | ||
| Recipient factors | |||||
| Age (years) | |||||
| 18–24 | 1.13 | 0.092 | |||
| 25–34 | 0.74 | <0.001 | 0.60 | <0.001 | |
| 35–44 | 0.76 | <0.001 | 0.56 | <0.001 | |
| 45–54 | 0.89 | 0.001 | 0.57 | <0.001 | |
| 55–64 | 1.35 | <0.001 | 0.71 | .004 | |
| ≥65 | 1.57 | <0.001 | 0.85 | 0.263 | |
| Blood group | |||||
| A | 0.94 | 0.046 | 0.96 | 0.313 | |
| B | 0.98 | 0.679 | |||
| O | 1.04 | 0.176 | |||
| AB | 1.17 | 0.025 | 1.18 | 0.044 | |
| BMI | |||||
| <18.5 | 0.90 | 0.019 | 0.95 | 0.543 | |
| 18.5–24.9 | 0.93 | 0.013 | 0.92 | 0.182 | |
| 25.0–29.9 | 1.15 | <0.001 | 1.04 | 0.532 | |
| 30.0–34.9 | 1.08 | 0.171 | |||
| 35.0–39.9 | 0.93 | 0.622 | |||
| ≥40.0 | 1.54 | 0.223 | |||
| Diagnosis | |||||
| Alpha-1-antitrypsin deficiency | 0.85 | 0.003 | Reference | ||
| COPD/emphysema | 1.29 | <0.001 | 1.11 | 0.088 | |
| Cystic fibrosis | 0.75 | <0.001 | 1.00 | 0.957 | |
| IPF/UIP | 1.13 | 0.004 | 1.02 | 0.744 | |
| Pulmonary hypertension | 0.80 | 0.004 | 1.00 | 0.967 | |
| GFR (mL/min) | |||||
| <10 | 2.01 | 0.001 | 2.02 | 0.012 | |
| 10–19 | 0.67 | 0.329 | |||
| 20–29 | 1.22 | 0.436 | |||
| 30–39 | 1.04 | 0.788 | |||
| 40–49 | 1.01 | 0.955 | |||
| ≥50 | 0.94 | 0.347 | |||
| Life support before transplant | 0.78 | 0.012 | 0.84 | 0.096 | |
| Waitlist time | |||||
| <6 months | 1.15 | <0.001 | 0.99 | 0.772 | |
| 6 months to 1 year | 1.12 | 0.001 | Reference | ||
| 1–2 years | 0.91 | 0.007 | 0.93 | 0.143 | |
| >2 years | 0.75 | <0.001 | 0.83 | 0.001 | |
| Donor/transplant factors | |||||
| Donor age (years) | |||||
| <15 | 0.96 | 0.575 | |||
| 15–24 | 0.95 | 0.081 | |||
| 25–34 | 0.94 | 0.095 | |||
| 35–44 | 1.11 | 0.009 | 1.08 | 0.097 | |
| 45–54 | 1.06 | 0.178 | |||
| ≥55 | 1.08 | 0.341 | |||
| Donor cause of death | |||||
| CVA | 1.08 | 0.014 | Reference | ||
| Anoxia | 0.81 | 0.009 | 0.80 | 0.012 | |
| Head trauma | 0.93 | 0.026 | 0.90 | 0.009 | |
| Donor cigarette use | 1.09 | 0.022 | 1.07 | 0.062 | |
| Donor ethnicity: African American | 1.06 | 0.007 | 1.03 | 0.317 | |
| Donor GFR (mL/min) | |||||
| <10 | 0.91 | 0.509 | |||
| 10–19 | 1.08 | 0.599 | |||
| 20–29 | 1.28 | 0.016 | 1.34 | 0.011 | |
| 30–39 | 1.03 | 0.736 | |||
| 40–49 | 1.03 | 0.664 | |||
| ≥50 | 0.94 | 0.169 | |||
| Gender match | |||||
| Male to male | 1.04 | 0.168 | |||
| Male to female | 1.07 | 0.071 | |||
| Female to male | 0.99 | 0.891 | |||
| Female to female | 0.90 | 0.002 | 0.90 | 0.017 | |
| ABO incompatible | 1.06 | 0.936 | |||
| HLA mismatch level | |||||
| 0 | 1.36 | 0.661 | |||
| 1 | 0.78 | 0.265 | |||
| 2 | 0.85 | 0.069 | |||
| 3 | 0.88 | 0.006 | 0.87 | 0.012 | |
| 4 | 1.01 | 0.677 | |||
| 5 | 0.99 | 0.818 | |||
| 6 | 1.13 | 0.001 | 1.08 | 0.079 | |
| Ischemic time (hours) | |||||
| <1.0 | 0.92 | 0.694 | |||
| 1.0–1.9 | 1.30 | <0.001 | 1.22 | 0.017 | |
| 2.0–2.9 | 1.18 | <0.001 | 1.06 | 0.325 | |
| 3.0–3.9 | 1.18 | <0.001 | 1.09 | 0.101 | |
| 4.0–4.9 | 0.98 | 0.611 | |||
| ≥5.0 | 0.75 | <0.001 | 0.99 | 0.858 | |
| Size match: undersized donor | 0.98 | 0.734 | |||
| Size match: oversized donor | 0.99 | 0.827 | |||
| Unilateral lung transplant | 1.58 | <0.001 | 1.31 | <0.001 | |
P<0.05 is significant on multivariable analysis. BMI, body mass index; COPD, chronic obstructive pulmonary disease; IPF/UIP, idiopathic pulmonary fibrosis/usual interstitial pneumonitis; GFR, glomerular filtration rate; CVA, Cerebrovascular accident; HLA, human leukocyte antigen.