Table 1. Baseline characteristics of the patients in the durvalumab plus chemotherapy (durvalumab) versus atezolizumab plus chemotherapy (atezolizumab) groups.
Characteristics | Durvalumab (N=100) | Atezolizumab (N=43) | P |
---|---|---|---|
Median age [range], years | 61 [23–82] | 64 [43–81] | 0.54 |
Age group, n [%] | 0.9 | ||
<65 years | 57 [57] | 24 [56] | |
≥65 years | 43 [43] | 19 [44] | |
Sex, n [%] | 0.3 | ||
Men | 72 [72] | 29 [67] | |
Women | 28 [28] | 14 [33] | |
ECOG performance status, n [%] | 0.83 | ||
≤1 | 94 [94] | 40 [94] | |
≥2 | 6 [6] | 3 [6] | |
Smoking status, n [%] | 0.27 | ||
Never | 60 [60] | 27 [63] | |
Current | 33 [33] | 10 [23] | |
Former | 7 [7] | 6 [14] | |
Disease stage at initiation of immunotherapy, n [%] | 0.13 | ||
Limited stage | 10 [10] | 9 [21] | |
Extensive stage | 90 [90] | 34 [79] | |
Brain or central nervous system metastasis, n [%] | 0.37 | ||
Yes | 23 [23] | 7 [16] | |
No | 77 [77] | 36 [83] | |
Liver metastases, n [%] | |||
Yes | 14 [14] | 5 [12] | 0.7 |
No | 86 [86] | 38 [88] | |
Bone metastases, n [%] | 0.08 | ||
Yes | 33 [33] | 8 [19] | |
No | 67 [67] | 35 [81] | |
Radiotherapy, n [%] | 0.06 | ||
Yes | 42 [42] | 32 [74] | |
No | 58 [58] | 11 [26] | |
Brain radiotherapy, n [%] | 0.07 | ||
Yes | 22 [22] | 4 [9] | |
No | 78 [78] | 39 [91] | |
Immunotherapy at the first line, n [%] | 0.14 | ||
Yes | 71 [71] | 29 [67] | |
No | 29 [29] | 14 [33] |
ECOG, Eastern Cooperative Oncology Group.