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. 2023 Jun 22;15:1200445. doi: 10.3389/fnagi.2023.1200445

FIGURE 2.

FIGURE 2

Intranasally administered hiPSC-NSC-EVs incorporate into NeuN + neurons in forebrain regions in naïve and 5xFAD mice. The figure illustrates the incorporation of EVs into NeuN + neurons in different forebrain regions of naïve (A–F,M–R) and 5xFAD mice (G–L,S–X) at 45 min (n = 4/group, A–L) and 6 h (n = 4/group, M–X) post-administration. The bar charts (Y,Z) compare the percentages of neurons incorporating EVs in different brain regions between naïve and 5xFAD mice at 45 min (Y) and 6 h (Z) post-administration. ECX, entorhinal cortex; mPFC, medial prefrontal cortex; OB, olfactory bulb; SSC, somatosensory cortex. Scale bar, 12.5 μm.