Overview of causes of PH in SCD. PH in SCD patients may be due to multiple different etiologies and often with multiple underlying causes. An overview of the different etiologies, their hemodynamics, and therapeutic options are listed. BPA, balloon pulmonary angioplasty; CTEPH, chronic thromboembolic PH; mPAP, mean pulmonary artery pressure; OSA, obstructive sleep apnea; PAOP, pulmonary artery occlusion pressure; PVR, pulmonary vascular resistance. (From Prohaska CC, Machado RF. The different facets of sickle cell disease-related pulmonary hypertension. Curr Opin Pulm Med. Sep 1 2021;27(5):319–328.)