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. 2023 Jan 21;17(7):1356–1378. doi: 10.1002/1878-0261.13370

Fig. 1.

Fig. 1

SALL4 expression is a prognostic biomarker in pancreatic ductal adenocarcinoma. (A) Kaplan–Meier curves of overall survival for 257 patients with localized pancreatic carcinoma in the ICGC cohort. Groups were split by high (red) or low (blue) levels of SALL4 expression (best cutoff) and compared using the log‐rank test. Hazard ratio modelization with 95% confidence intervals by restricted cubic spline according to SALL4 expression. (B) Kaplan–Meier curves of overall survival for 288 patients with localized pancreatic carcinoma in the GSE85916 cohort. Groups were split by high (red) or low (blue) levels of SALL4 expression (best cutoff) and compared using the log‐rank test. Hazard ratio modelization with 95% confidence intervals by restricted cubic spline according to SALL4 expression. (C) Boxplots and barplots comparing the distribution of the SALL4 expression in different tumor stages in the ICGC cohort, including advanced stages (stages III and IV, n = 13 available patients). (D) Boxplots and barplots comparing the distribution of the SALL4 expression in basal/classical and activated/normal stroma subtypes from the Moffit classification [3] and Puleo classification [5] for 259 patients with localized pancreatic carcinoma in the ICGC cohort. Boxplots show the median and interquartile range. Medians were compared using Student's t‐tests.