Table 2.
Distributions of inflammatory biomarkers, by study visit, among 818 women in PROTECT.
| Visit | N | Min | p25 | Med | p75 | p90 | Max | GM | SD | IQR | ICC (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRP | 1 | 623 | 86675 | 1920120 | 3816094 | 6611702 | 11294355 | 32013346 | 3349068 | 4625260 | 4691582 | 0.68 (0.62, 0.74) |
| 3 | 411 | 132096 | 1667929 | 3588576 | 6913178 | 12282266 | 53806064 | 3219248 | 5370313 | 5245249 | ||
| MMP1 | 1 | 731 | 1.58 | 156 | 312 | 558 | 1020 | 4301 | 295 | 504 | 402 | 0.79 (0.74, 0.82) |
| 3 | 479 | 7.84 | 190 | 380 | 665 | 1261 | 6006 | 356 | 595 | 475 | ||
| MMP2 | 1 | 743 | 698 | 7935 | 9446 | 11430 | 26805 | 79722 | 10740 | 12644 | 3495 | 0.77 (0.73, 0.81) |
| 3 | 487 | 4690 | 7838 | 9261 | 10868 | 14488 | 71698 | 9907 | 8974 | 3030 | ||
| MMP9 | 1 | 716 | 978 | 23439 | 33419 | 46046 | 57445 | 159501 | 31810 | 17693 | 22607 | 0.49 (0.40, 0.56) |
| 3 | 468 | 1700 | 22399 | 32707 | 45025 | 55720 | 119523 | 31106 | 17059 | 22626 | ||
| ICAM | 1 | 698 | 85337 | 506320 | 609455 | 781580 | 1051434 | 8172562 | 646066 | 506357 | 275261 | 0.86 (0.83, 0.88) |
| 3 | 450 | 218407 | 500036 | 607207 | 791400 | 1188143 | 9983930 | 662515 | 641760 | 291364 | ||
| VCAM | 1 | 686 | 37339 | 206742 | 253639 | 305048 | 367289 | 788578 | 243715 | 86844 | 98307 | 0.47 (0.38, 0.55) |
| 3 | 455 | 57195 | 215569 | 263873 | 319075 | 377158 | 1440323 | 260460 | 106129 | 103506 |
All biomarkers were measured above the limit of detection (LOD) in 100% of samples. All concentrations are presented in pg/mL.
GM: geometric mean; SD: standard deviation; IQR: interquartile range; ICC: intraclass correlation coefficient; CI: confidence interval.