Table 3.
Effect estimates and 95% confidence intervals from linear mixed effects models for the associations between phthalate metabolites and inflammatory biomarkers among 818 women in PROTECT. Estimates refer to the percent change in inflammatory biomarker with an interquartile range increase in phthalate metabolite.
| CRP | ICAM | VCAM | MMP1 | MMP2 | MMP9 | |
|---|---|---|---|---|---|---|
| MBP | 4.91 (−3.82, 14.42) | −0.53 (−3.23, 2.26) | 0.38 (−2.84, 3.71) | 7.86 (0.49, 15.76) | 2.06 (−1.94, 6.23) | −0.69 (−5.31, 4.15) |
| MHBP | 4.50 (−8.04, 18.75) | −0.75 (−4.64, 3.30) | 0.50 (−4.16, 5.38) | 0.00 (−9.44, 10.42) | 5.49 (−0.79, 12.17) | −6.24 (−12.29, 0.22) |
| MIBP | 1.48 (−7.51, 11.35) | −1.60 (−4.63, 1.54) | −1.79 (−5.08, 1.62) | 3.15 (−4.59, 11.53) | 0.03 (−4.22, 4.47) | 0.82 (−4.03, 5.92) |
| MHIBP | 7.85 (−5.47, 23.05) | −3.26 (−7.47, 1.15) | −2.69 (−7.20, 2.04) | −1.57 (−11.45, 9.41) | −3.59 (−9.74, 2.99) | −0.70 (−7.13, 6.16) |
| MEP | 0.43 (−8.08, 9.72) | −2.71 (−5.63, 0.31) | −1.60 (−4.78, 1.68) | 3.38 (−4.04, 11.37) | −1.80 (−5.82, 2.39) | 0.42 (−4.21, 5.27) |
| MEHP | −2.50 (−10.89, 6.69) | −3.55 (−6.42, −0.59) | −0.81 (−4.12, 2.61) | −1.50 (−8.59, 6.14) | 0.15 (−3.98, 4.45) | 2.12 (−2.78, 7.28) |
| MEHHP | 5.19 (−3.13, 14.23) | −1.40 (−3.98, 1.24) | −1.35 (−4.35, 1.75) | 1.21 (−5.33, 8.19) | −0.49 (−4.16, 3.32) | −0.23 (−4.61, 4.35) |
| MEOHP | 3.63 (−4.58, 12.54) | −1.63 (−4.20, 1.02) | −1.06 (−4.09, 2.07) | 2.81 (−3.86, 9.95) | −0.52 (−4.20, 3.31) | −0.71 (−5.11, 3.89) |
| MECPP | 7.00 (−2.15, 17.01) | −1.05 (−3.84, 1.82) | −0.53 (−3.75, 2.79) | 3.38 (−3.78, 11.08) | −1.83 (−5.73, 2.23) | −1.63 (−6.23, 3.18) |
| MCOP | 2.13 (−5.03, 9.83) | −0.29 (−2.59, 2.07) | −0.15 (−2.82, 2.60) | 1.94 (−3.92, 8.16) | −2.31 (−5.50, 0.98) | −3.50 (−7.18, 0.32) |
| MONP | −5.20 (−15.64, 6.53) | −1.32 (−4.31, 1.76) | −3.47 (−7.67, 0.93) | 5.11 (−2.70, 13.54) | 8.30 (2.22, 14.75) | −1.55 (−7.40, 4.68) |
| MCNP | 2.33 (−4.73, 9.91) | 0.39 (−1.82, 2.65) | 1.43 (−1.29, 4.23) | 0.81 (−4.81, 6.76) | −4.51 (−7.53, −1.40) | −1.92 (−5.71, 2.02) |
| MCPP | 2.64 (−5.55, 11.53) | 0.22 (−2.41, 2.92) | −0.11 (−3.11, 2.98) | 1.05 (−5.45, 8.01) | 0.25 (−3.42, 4.05) | −1.58 (−5.81, 2.84) |
| MBZP | −0.61 (−9.07, 8.65) | −1.07 (−4.00, 1.95) | 1.44 (−1.88, 4.88) | 5.48 (−2.15, 13.71) | 0.51 (−3.65, 4.85) | 0.19 (−4.53, 5.14) |
| MECPTP | 7.08 (−3.39, 18.69) | 2.45 (−0.61, 5.61) | −0.18 (−4.17, 3.99) | 3.62 (−3.90, 11.73) | 1.15 (−4.56, 7.20) | −6.62 (−11.87, −1.05) |
| MEHHTP | 11.83 (−1.45, 26.90) | 3.29 (−0.45, 7.18) | 0.52 (−4.39, 5.67) | 1.84 (−7.10, 11.65) | 0.30 (−6.55, 7.64) | −6.53 (−12.88, 0.28) |
All models adjust for categorical maternal education, continuous maternal age and pre-pregnancy BMI, and specific gravity.