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. 2023 Jun 21;17:1202099. doi: 10.3389/fnbeh.2023.1202099

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Copyright © 2023 Dunn, Robinson, Nwokafor, Estill, Ferrante, Shen, Lemchi, Creus-Muncunill, Ramirez, Mengaziol, Brynildsen, Leggas, Horn, Ehrlich and Blendy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of transcriptome analysis (A) Volcano plots of DEGS from RNA seq from male and female PND14 mice. Log2 fold changes are in the same value range observed for all 6 datasets. In these plots, significant and non-significant myelin-associated genes are highlighted, discussed in more detail in the text. (B) Venn diagrams showing low numbers of overlapping DEGs (Adj p value < 0.05) across treatment group (labeled) and across sex. (C,D) Bar graphs showing total number of DEGS in males and females from all 3 exposure protocols. Top graph numbers represent DEGs with nominal significance p < 0.05 whereas bottom graphs represent DEGs with adjusted p < 0.05 (D).