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. Author manuscript; available in PMC: 2023 Jul 6.
Published in final edited form as: Clin Cancer Res. 2022 Dec 15;28(24):5317–5329. doi: 10.1158/1078-0432.CCR-22-2103

Figure 3. T cell clonal analysis.

Figure 3.

A. T cell clonality determined by TCRβ sequencing in TIL and six-week apheresis samples. B. Persistence in vivo measured by Overlap metric in TCRβ sequences between TIL and six-week apheresis sample. C. Absolute number of clones categorized by relative frequency between TIL infusion and six-week apheresis. D. Ratio of T cell clones with increased frequency (expanding) to decreased frequency (contracting) from infused TIL product to six-week time point. Mann-Whitney test. E. Clonal tracking by TCRβ sequence of the top ten infused TIL clones in peripheral blood samples from long-term responders. F. Stacked productive frequency of the top twenty-five shared T cell clones across long-term responders in peripheral blood. Colors indicate time point of clonal origin as indicated.