Table 1.
Accessibility of the Single-Cell RNA-Sequencing Data on Murine and Human Lung Tissues Used in This Study
| Species | Treatment/Model/Disease | GEO ID | Numbers of Tissues (n) |
Collection Timepoint | Dissociation Reagent | Instrument Model | References | |
|---|---|---|---|---|---|---|---|---|
| Fibrosis | Normal | |||||||
| Murine | Bleomycin/adult | GSE111664 | 3 | 7 | Day 14 | Liberase | MiSeq | 20 |
| GSE129605 | 4 | 4 | Day 11 | Collagenase A | NextSeq 500 | 21 | ||
| GSE131800 | 1 | 1 | Day 21 | Elastase | NovaSeq 6000 | 22 | ||
| GSE104154 | 1 | 1 | Day 21 | Elastase | NextSeq 500 | 9 | ||
| GSE132771 | 4 | 4 | Day 14 | Collagenase A | HiSeq 4000 | 23 | ||
| Bleomycin/aged | GSE157379 | 3 | 3 | Day 14 | Collagenase IV | NextSeq 500 | 10 | |
| Silica/adult | GSE184854 | 12 (Days 7 and 21) | 5 (Day 3) | Days 3, 7, and 21 | Liberase | NovaSeq 6000 | 24 | |
| Human | IPF | GSE136831 | 32 | 28 | NA | Elastase/liberase | HiSeq 4000 | 12 |
| GSE157376 | 5 | 5 | NA | Elastase | NextSeq 500 | 10 | ||
| GSE128169 | 0 | 5 | NA | Collagenase A | NextSeq 500 | 25 | ||
| GSE135893 | 12 | 10 | NA | Collagenase I | NovaSeq 6000 | 11 | ||
| GSE128033 | 8 | 10 | NA | Collagenase A | NextSeq 500 | 26 | ||
| GSE122960 | 4 | 8 | NA | Collagenase D | HiSeq 4000 | 27 | ||
| GSE132771 | 6 | 6 | NA | Collagenase A | NovaSeq 6000 | 23 | ||
| SSc-ILD | GSE159354 | 2 | 5 | NA | Collagenase I | HiSeq 4000 | 28 | |
| GSE132771 | 6 | 4 | NA | Collagenase A | NovaSeq 6000 | 23 | ||
| COVID-19 | GSE171524 | 19 | 7 | NA | NA | NovaSeq 6000 | 29 | |
| COVID-19 late-stage | GSE158127 | 3 | 3 | NA | Collagenase D | HiSeq 4000 | 30 | |
Definition of abbreviations: COVID-19 = coronavirus disease; GEO = gene expression omnibus; IPF = idiopathic pulmonary fibrosis; NA = not associated; SSc-ILD = systemic sclerosis–associated interstitial lung disease.
Bleomycin/adult indicates bleomycin-induced lung fibrosis in adult mice; bleomycin/aged indicates bleomycin-induced lung fibrosis in aged mice; silica/adult indicates silica-induced mouse lung fibrosis.