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. 2023 Jul 6;11:138. doi: 10.1186/s40168-023-01578-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — mRNA expression of CAR correlates with Abcb1a levels in mouse intestine. In mice, the transcription factor CAR is encoded by the Nr1i3 gene. A Comparison of the mRNA expression of Nr1i3 in the proximal, median and distal small intestine; in the colon; and in the liver of control and ATB-treated mice, with or without TAC treatment (n = 7–8/group). ^#significant ATB effect; ^$significant TAC effect; ***p < 0.001, **p < 0.01, and *p < 0.05. B Spearman’s correlation between Nr1i3 and Abcb1a mRNA expression levels in the different tissues