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. 2023 Jul 6;11:138. doi: 10.1186/s40168-023-01578-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Polar bacterial metabolites impact the transcriptional regulation of ABCB1, but not directly its functionality. A ABCB1 substrate (rhodamine 123) intracellular accumulation (in relative fluorescent units, r.f.u.) with or without a 15 min pre-exposition to mouse faecal water (FW) in control plasmid or in ABCB1-transfected cells (n = 6/group, N = 2). ***p < 0.001. B Comparison of the mRNA expression of ABCB1 in control Caco-2 cells (PBS) or cells exposed to mouse FW for 48 h (n = 3/group, N = 5). ***p < 0.001. C Comparison of the mRNA expression of ABCB1 in control Caco-2 cells (PBS) or cells exposed for 48 h to FW from untreated mice (FWctl), or to FW from ATB-treated mice (FWatb), or to antibiotics (ATB) (n indicated on the figure, for FW n = 7 biological replicates). *p < 0.05 and.^###p < 0.001 (paired t-test between FWctl and Fwatb)