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. Author manuscript; available in PMC: 2023 Jul 6.
Published in final edited form as: Alcohol Clin Exp Res (Hoboken). 2023 Feb 17;47(3):470–485. doi: 10.1111/acer.15019

FIGURE 2.

FIGURE 2

Indomethacin rescues adolescent intermittent EtOH (AIE)-induced loss of the immature neuron marker doublecortin (DCX) in the adult dorsal dentate gyrus in male and female rats. (A) Photomicrographs of DCX+ immunoreactivity (IR). Scale bar indicates 100 μm. (B) Expression of DCX + IR in adulthood is significantly reduced in AIE-treated females by 29% and in AIE-treated males by 33%, p’s < 0.05. Chronic treatment with the nonsteroidal anti-inflammatory compound indomethacin rescues this deficit in both sexes (males: blue, females: pink), suggesting restoring the neuroinflammatory balance in the neurogenic niche is essential to recovering neurogenic deficits after AIE. Sections were quantified as immunoreactive pixels per mm2. Data are expressed as mean ± SEM. *p < 0.05 between indicated groups.