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. 2023 Jul 5;22:55. doi: 10.1186/s12941-023-00606-x

Table 1.

Antibiotic susceptibility of three XDR P. aeruginosa collected from the patient during the clinical course

Antibiotics MICs (mg/L)
Endotracheal secretion samples Abdominal tissue sample
hospital day 13 hospital day 17 hospital day
27
ISOLATE 1 ISOLATE 2 ISOLATE 3
Cefepime > 64 > 64 > 64
Cefepime/zidebactam 16 16 16
Ceftazidime > 64 > 64 > 64
Ceftazidime/avibactam > 64 > 64 > 64
Imipenem > 64 > 64 > 64
Imipenem/relebactam > 64 > 64 > 64
Ceftolozane/tazobactam > 64 > 64 > 64
Piperacillin/tazobactam > 64 > 64 > 64
Meropenem > 64 > 64 > 64
Amikacin > 64 > 64 > 64
Levofloxacin > 64 > 64 > 64
Fosfomycin > 256 > 256 > 256
Colistin 0.25 0.25 0.25
Polymyxin B 0.12 0.25 0.25
Imipenem + EDTA 16 16 16
Ceftazidime/avibactam + EDTA 16 16 16

Cefepime/zidebactam MICs were determined in 1:1 ratio;

For all the β-lactamase inhibitor based combination, inhibitor was at fixed 4 mg/L

EDTA: Ethylene diamine tetraacetic acid at fixed 200 mg/L

For fosfomycin, agar MIC method was employed by supplementing the medium with glucose-6-phosphate at 25 mg/L