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. 2023 Jul 6;15:104. doi: 10.1186/s13148-023-01519-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Placental methylation is significantly associated with THC exposure across the genome. A Manhattan plot of CpGs in placenta associated with prenatal THC exposure with the uncorrected log10 (p values) plotted on the y-axis and chromosomal location on the x-axis (Mmul_10). The blue line is drawn to indicate CpGs that surpassed p value < 1e−5, a threshold for suggestive association, and the red line is to highlight CpGs that passed a stringent Bonferroni threshold of p value < 2e−07. B Heatmap of placental DMCs passing FDR significance (n = 573 CpGs) clearly separate by treatment group. Values represent the log-transformed and mean centered average methylation values per CpG. C Prenatal THC is associated with methylation changes in placental MEGF10 promoter. Gviz plot [4] showing from top to bottom the gene structure, CpG island proximity, and individual CpG beta values for each animal (THC animals are shown in pink and Control in blue)