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. 2023 Jul 6;15:104. doi: 10.1186/s13148-023-01519-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Candidate autism spectrum disorder genes are enriched among prenatal THC-DMCs for each tissue type. A UpSet plot of the overlap of SFARI genes annotated to one or more DMC for each tissue. The y-axis represents the number of intersections for each combination of sets across the x-axis. Twenty-nine SFARI genes were represented in DMC lists across all five tissues. B THC-DMC-associated genes were tested for enrichment for SFARI genes across a range of p value thresholds. The x-axis indicates p value threshold for association and the y-axis indicates the − log10 p value for enrichment at each threshold. Line colors represent unique tissues. C Venn diagram demonstrates the overlap of genes annotated to ASD DMRs in a prospective birth cohort study (MARBLES) with placental THC DMC genes. The hypergeometric test was used to test for significance of overlap