Skip to main content
. Author manuscript; available in PMC: 2023 Jul 6.
Published in final edited form as: J Thorac Oncol. 2021 Jul 24;16(12):2051–2064. doi: 10.1016/j.jtho.2021.07.007

Figure 2. Estrogen induces resistance to bevacizumab, anti-VEGF, treatment in NSCLC xenografts.

Figure 2.

Nude ovariectomized mice were primed with slow releasing estrogen (80pg/ml) tube. Mice were treated with bevacizumab (BV) 10mg/kg in the presence or absence of estrogen. Mice were sacrificed when tumor size reaches 1000mm3. Kaplan-Meier plot shows survival distribution of mice treated with BV in (A) A549 (B) HCC827 xenografts. The log-rank (Mantel-Cox) test was used to compare the statistical differences among the groups. N =10 mice per group and experiment was performed twice.