Figure 4.

(A) Structure of ID-probe 4 (left) that can differentiate between specific populations of isoforms in biological mixtures and in living cells (right). (B) Representative emission patterns generated by 4 in the absence (black) and presence of GST-M-1 (magenta), MMP-12 (green), MMP-14 (blue), or PDGF-BB (gray). (C) LDA of the patterns generated by 4 in response to different isoform combinations in human urine. (D) LDA differentiation of nonengineered cells loaded with 4 after being subjected to heat, H₂O₂- induced oxidative stress, an inflammatory agent (LPS), or pharmaceuticals (picoline or carnosol). Adapted with permission from ref (3). Copyright 2017 Springer Nature.