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. 2023 Mar 7;29(7):1981–1998. doi: 10.1111/cns.14154

FIGURE 9.

FIGURE 9

Intrathecal injection of the FXR agonist INT‐747 alleviated the mechanical allodynia in SNI mice, and the effects were blocked by FXR or GABAA antagonist. (A, B) A single intrathecal injection of INT‐747 on day 7 after SNI dose dependently attenuated mechanical allodynia in the ipsilateral (A) and contralateral hind paw (B) in SNI mice (n = 5 or 6/group). (C, D) The effect of INT‐747 (25 μg) on the 50% paw withdrawal threshold in bilateral hind paws was blocked by FXR antagonist Z‐guggulsterone (n = 6/group). (E, F) The effect of INT‐747 on the 50% paw withdrawal threshold in bilateral hind paws was blocked by bicuculline (n = 6/group). ***p < 0.001, ****p < 0.0001 compared with SNI on day 7, Friedman ANOVA for repeated measurements, followed by the Wilcoxon matched‐pairs test.